Showing posts with label that. Show all posts
Showing posts with label that. Show all posts
Tuesday, June 20, 2017
and hey would you look at that heres a Brooks post for you!
and hey would you look at that heres a Brooks post for you!
Yep, thats right, my latest Brooks post is up, lucky you!

(Apologies for making you look at Bruce Springsteen.)
Ill let you know if any of my other guest-posting endeavors materializes during my absence, but pending that Im out until Tuesday September 6th.
Happy Laborious Day!
--Wildcat Rock Machine

Available link for download
Wednesday, May 24, 2017
Amicus Brief Filed By Alnylam Pharmaceuticals Argues That Funk Bros Is About Obviousness Not Patent Eligibility
Amicus Brief Filed By Alnylam Pharmaceuticals Argues That Funk Bros Is About Obviousness Not Patent Eligibility
Alnylam Pharmaceuticals is a biopharmaceutical company based in Cambridge, Massachusetts focused on developing synthetic "small interfering RNAs" (SiRNAs) as therapeutic agents. It has filed an amicus curiae brief in the Myriad gene patent case (AMP v. US PTO) that makes a number of insightful points, particularly in attempting to "debunk myths of Funk Brothers Seed Co. v. Kalo Inoculant Co."
Funk Brothers is generally assumed to be a case about patent eligibility. However, Alnylam points out that Funk Brothers was decided by the Supreme Court in 1948, prior to the enactment of the 1952 patent statute and thus prior to 35 USC 101, which is the statutory basis for the patent eligibility doctrine. Prior to 1952, the Court used the term invention to refer to "inventiveness," a concept that subsequent to 1952 and the enactment of 35 USC 103 we refer to as "nonobviousness." The Court in Funk Brothers found the claimed subject matter was not the product of invention, but Alnylam argues that post-1952 this statement should be interpreted a finding of obviousness, not patent ineligibility.
I have always found it extremely difficult, if not impossible, to find a principled distinction between the inventions claimed in Funk Brothers and Diamond V. Chakrabarty that would justify finding only Dr. Chakrabartys invention patent eligible. In Funk Brothers, the alleged invention was a novel and useful combination, in a single inoculant, of naturally occurring microorganisms in a combination that did not exist naturally. Chakrabartys invention was a novel and useful combination, in a single microorganism, of naturally occurring plasmids in a combination that did not exist naturally. It is important to bear in mind that Chakrabartys invention did not involve any genetic engineering at the molecular level.
In Funk Brothers, it has been pointed out that while the combination of bacteria in a single inoculant was novel, the bacteria function in the same manner and have the same characteristics as they would have in nature. But the same can be said regarding the plasmids Dr. Chakrabarty introduced into a single microorganism. These were naturally occurring plasmids, and in the claimed microorganism they encoded the exact same proteins, and performed the exact same function as they did in their natural state.
In a nutshell, Funk Brothers was a novel combination of naturally occurring bacteria capable of achieving novel and useful function, with the bacteria functioning in the same manner as they do in nature. Chakrabarty was a novel combination of naturally occurring plasmid DNA capable of achieving novel and useful function, with the plasmid DNA functioning in the same manner as they do in nature. I dont see how one invention can be patent eligible and the other not. However, if Funk Brothers was really decided based on obviousness rather than patent eligibility, as argued by Alnylam, the two decisions are easily reconciled.
Available link for download
Amgen Sues Hospira Claims That Biosimilar Version of Epogen Infringes
Amgen Sues Hospira Claims That Biosimilar Version of Epogen Infringes
In Amgen v. Sandoz, a fractured panel of the Federal Circuit held that an applicant seeking approval of a biosimilar under the abbreviated BPCIA pathway is not required to participate in the so-called patent dance, and that if a biosimilar applicant fails to provide the reference product sponsor with its application and the other patent dance information, then the reference product sponsors only recourse is to bring a declaratory judgment action for patent infringement.
On September 18, Amgen did just that, filing a lawsuit against Hospira alleging that Hospiras planned marketing of a biosimilar version of Amgens biologic Epogen (epoiten alfa) infringes Amgen patents. The complaint is available here.
Amgen states that this is one of the first actions for patent infringement under 35 USC 271(e)(2)(C), which was enacted in 2010 as part of the BPCIA.
Amgen states that this is one of the first actions for patent infringement under 35 USC 271(e)(2)(C), which was enacted in 2010 as part of the BPCIA.
According to the complaint, Hospira submitted its Biologic License Application (BLA) under the expedited subsection (k) pathway, relying on Amgens demonstration of the safety and efficacy of Epogen, but has failed to comply with the patent provisions of the BPCIA. For example, Hospira has not provided Amgen with manufacturing information that would have given Amgen the opportunity to evaluate the manufacturing processes used by Hospira to determine whether those processes would infringe any patents held by Amgen. This is essentially the same complaint Amgen had with respect to Sandozs application for expedited approval of a biosimilar filigrastim based on Amgens Neupogen product.
Amgen is also seeking a declaratory judgment that Hospira is required to provide Amgen with legally effective notice of commercial marketing of its biosimilar product, and information describing the processes or products used to manufacture the biosimilar product. In Amgen v. Sandoz, the Federal Circuit held that a biosimilar applicant must provide notice to the reference sponsor on or after the date that the FDA approves its biosimilar application, but according to the complaint Hospira has refused to do so.
Available link for download
Monday, May 15, 2017
All About That Lace
All About That Lace
I am nothing if not easily distracted. Whats below is the kind of thing that creeps into my notebooks when I am supposed to be doing serious work.
If Meghan Trainors bouncy ode to the curvaceous posterior, "All About That Bass",

can spawn a Star Wars version, a high school literacy version, and a forties jazz version, et al., I see no reason why we knitters should not have a version of our own.

can spawn a Star Wars version, a high school literacy version, and a forties jazz version, et al., I see no reason why we knitters should not have a version of our own.
I sing like a screech owl and havent got the time to make a video (perhaps the Mason-Dixon ladies will oblige?), but heres my contribution to the boom boom on the dance floor.
Because you know
Im all about that lace, bout that lace,
No cables.
Im all about that lace, bout that lace,
No cables.
Im all about that lace, bout that lace,
No cables.
Im all about that lace,
Bout that lace, lace, lace.
Yeah, its pretty clear
I need a size 2.
Cause I been swatching, swatching,
Like Im supposed to do.
Cause I know what you need to make it all lace
All the right holes in all the right places.
The knitting magazines down at the local shop,
You want a pretty shawl? They got a bumper crop.
Yarn over, knit together, and never stop
Til every inch of it is perfect
From the bottom to the top.
You know my mama she told me dont worry about the size,
She said a shawl can be tiny or cover you to the thighs.
You know I wont knit your sweater for Christmas like Santas elf.
So if thats what you want you can knit it your own damn self.
Because you know
Im all about that lace, bout that lace,
No cables.
Im all about that lace, bout that lace,
No cables.
Im all about that lace, bout that lace,
No cables.
Available link for download
And in that moment I swear we were infinite
And in that moment I swear we were infinite


Coat from Mango
Boots from Ash via Zalando
Sweater from Esprit
Scarf from New Yorker
Beanie from Tally Weijl
Available link for download
Sunday, March 12, 2017
All That Jazz
All That Jazz
In 1979 I saw the film All
That Jazz for the first time.
I sat in the movie theater
watching Joe Gideon, Bob
Fosses alter ego, destroying
himself in the name of sex,
drugs, and musical theater.
On the way home, I had
much to think of. Fosse
had done me a fantastic favor.
Somehow, he had touched my heart, communicated with me in a
way no one else had. A core
paradox had been laid out
with surgical simplicity:
1) To achieve your full potential
requires monomaniacal focus.
2) Monomaniacal focus
creates imbalance.
3) Imbalance leads to skewed
values: Gideon was a man
turned inside-out, putting
his priorities on the very
things most likely to destroy him.
4) Premature self-destruction
prevents you from reaching
your full potential.
I dont know about anyone
else, but that movie was a
wake-up call on a massive,
soul-shaking level. I was
determined to be the absolute
best I could be, and the
path I saw to it was so rife
with peril that it was obvious
Id be riding a unicycle over
a pool of sharks. I puzzled
over this one for days, and
finally came to a life-changing
conclusion: the safest thing
to be obsessive about was
BALANCE. I would care
equally about all three basic
aspects of my life: body,
mind, and emotions. Then
let the chips fall where they may.
###
I was twenty-seven years
old when I saw All That
Jazz. Thinking about it
as deeply as possible,
whereas Ive read books
and seen films that taught
me interesting things about
the world, works of fiction
stopped changing me on
any deep level at that point.
NON-fiction continued to
do so strongly until my
40s, and from time to time
I still get a little bump
from some piece of philosophy
or physics or history.
But fiction? No.
On that level, stick a
fork in me, Im done.
I hear people speaking
of fiction, books or films
or plays, that shakes them
and changes their world
view or transforms them.
I was wondering what
was the last (or most recent)
work that changed you, and
how old were you when
that happened?
If YOU want to reach your
maximum without the risk
of destroying yourself, I
suggest the same approach
to balance.
The 101 Program teaches
this, as do all of my other
offerings. But the crown
of it all is personal coaching,
which is available on a
very, very limited basis only
to those who are totally
committed. I dont want to
waste your time, and I wont
let you waste mine. Make
no mistakewhen we
talk for 30-60 minutes a
week, phone or Skype,
miracles can and do happen.
If youre ready to take
your game to the next level,
I would suggest going to
www.diamondhour.com
and checking out the
terms required to work
with me personally. I
recently had two positions
open up in my coaching
schedule (I have to limit
the number of people,
or I wont have time for
my own work!)
If you have the passion
for change and are prepared
to invest in yourself, drop
me a line, and well have
a conversation about
possibilities.
Love, health, success.
And all that jazz.
Namaste,
Steve
Available link for download
Tuesday, February 28, 2017
All the amazing stuff that JKUnrein shared in her talk today
All the amazing stuff that JKUnrein shared in her talk today
This woman is a star and while not everything was new for me, shes an inspiration to see how much ground you can cover in 60 minutes.
Heres just a compilation of the tweets I put out just during here session. And just so we dont lose this in a years time, heres a list of the tweets from the talk:
Heres just a compilation of the tweets I put out just during here session. And just so we dont lose this in a years time, heres a list of the tweets from the talk:
- Do you want to see some amazing showcases of #html5 - check this out http://www.apple.com/html5/ @jkunrein attests this resource #LSCon
- One more type server for you to use with you #html5 content (not free) via @jkunrein at #lscon https://typekit.com/
- Adobe captivate #html5 encoder. They are really getting behind the new web. Via @jkunrein at #lscon http://labs.adobe.com/technologies/captivate_html5/
- Tumult Hype - @nickfloro mentioned it, I love it and now @jkunrein is telling us about it too! #html5 animation #lscon http://tumultco.com/hype/
- Another SWF converter that allows you to port over your animation to #HTML5 via @jkunrein at #lscon http://www.sothink.com/
- Weve used this encoding tool + player before - Brightcove via @jkunrein at her #html5 session at #lscon http://www.brightcove.com/en/
- And one more free player you can use with your web video content #html5 via @jkunrein at #lscon http://www.jplayer.org/
- Another video player you can use for web video #html5 via @jkunrein at #lscon http://videojs.com/
- A free #html5 video player you can use - Sublime #lscon via @jkunrein http://sublimevideo.net/
- Another video encoder for #html5 compatibility via @jkunrein #lscon http://zencoder.com/
- Studio style (pricey) video encoding for the web #lscon via @jkunrein http://www.telestream.net/
- Miro-A super simple way to convert almost any video to #html5 compatible formats #lscon via @jkunrein http://www.mirovideoconverter.com/
- Raphaël is a JavaScript library thatll simplify your work with vector graphics on the web #html5 via @jkunrein #lscon http://raphaeljs.com/
- Optimise your PNG files #html5 via @jkunrein at #lscon http://imageoptim.com/
- Surfacing this site since @jkunrein mentioned this in her talk today #html5 learning #lscon http://www.html5rocks.com/en/
- Use browser sniffing to figure out what browsers access your content so you can do different things for different platforms #lscon @jkunrein
- Parallax scrolling is an interesting content delivery mechanism Im seeing on websites and magazines. @jkunrein is showing it #LSCon
- Btw, for really enriching articles by @jkunrein keep checking out stuff she writes for #lsmag http://www.learningsolutionsmag.com/authors/304/judy-unrein #LSCon
- Check out the #html5 starling murmuration and dynamic video here http://www.thewildernessdowntown.com/ #lscon via @jkunrein
- For some reason I wasnt following @jkunrein. You should see her blog http://onehundredfortywords.com/ #LSCon
- @CUtrain: Loved the quote by @jkunrein Create interactive courses, "stop the navigation rage." @bschlenker what I learned yesterday #LSCON
© Sumeet Moghe
Available link for download
Thursday, February 2, 2017
Alkaline Foods That Fight Cancer Pain Gout Diabetes And Heart Disease
Alkaline Foods That Fight Cancer Pain Gout Diabetes And Heart Disease

Trying to go alkaline?
Its easier when you know which foods help your get to and stay in an alkaline state. A general rule of thumb is that you can eat these foods without worrying about any acidic effect theyll have, although some are more alkaline than others.
IT ISNT NECESSARY TO EAT ONLY ALKALINE FOODS IN ORDER TO GET BODYS PH LEVELS TO BE ALKALINE, AND A CERTAIN PERCENTAGE OF FOODS CAN BE ACIDIC, BUT ITS BEST IF THEYRE NATURAL, WHOLE FOODS LIKE FRUITS.
-
#1 ALMONDS

Almonds consistently rank on the list of healthiest foods to eat, so its no wonder that theyre also an alkaline food.
MOST NUTS AND SEEDS ARE CONSIDERED ACID UNLESS THEYRE SPROUTED; HOWEVER THERE ARE SOME THAT ARE NEUTRAL OR JUST SLIGHTLY ALKALINE SUCH AS ALMOND
Raw Foods Diet Center
Top stats (per 100g):
Calcium 27%
Iron 25%
Protein 44%
Calcium 27%
Iron 25%
Protein 44%
#2 AMARANTH

This is a grain that not many people are familiar with, but that makes a great addition to any alkaline-focused diet plan.
TODAY AMARANTH IS VALUED WORLDWIDE. THE UNITED NATIONS FOOD AND AGRICULTURE ORGANIZATION HAS FOSTERED AMARANTHS USE SINCE 1967 BECAUSE WHEREVER IT IS CONSUMED THERE IS NO MALNUTRITION. AMARANTH HAS MORE PROTEIN THAN WHEAT AND HIGHER IN THE AMINO ACID LYSINE THAN OTHER GRAIN SOURCES OF PROTEIN.
BOTANISTS NOTE THAT AMARANTH BELONGS TO A REMARKABLE GROUP OF PHOTOSYNTHETIC SUPER PERFORMERS CALLED THE C4 GROUP, MEANING IT IS SUPER EFFICIENT IN CONVERTING SOIL, SUNLIGHT, AND WATER INTO PLANT TISSUE.
Eden Foods
Top stats (per 100g):
Calcium 16%
Iron 42%
Protein 14g
Calcium 16%
Iron 42%
Protein 14g
#4 ARTICHOKES

Artichokes are often seen on top of salads, or used in a dip, but there are a number of reasons why you can bring them to the forefront of your diet.
ARTICHOKES HAVE THE HIGHEST ANTIOXIDANT LEVELS OUT OF ALL VEGETABLES, ACCORDING TO A STUDY DONE BY THE USDA, AND OUT OF 1,000 PLANTS DIFFERENT TYPES OF FOODS, THEY RANKED #7 IN ANTIOXIDANT CONTENT. ANTIOXIDANTS ARE ONE OF THE PRIMARY MEANS OF DEFENSE FOR THE IMMUNE SYSTEM AGAINST THE EFFECTS OF FREE RADICALS, NATURAL BYPRODUCTS OF CELL METABOLISM THAT CAN LEAD TO A NUMBER OF DANGEROUS CONDITIONS AND DISEASES IN THE BODY, INCLUDING CANCER AND HEART DISEASE, AMONG OTHERS.
Top stats (per 100g):
Vitamin C 20%
Vitamin K 12%
Folates 17%
Vitamin C 20%
Vitamin K 12%
Folates 17%
#5 ARUGULA

Heres a leafy green thats worth getting to know. Arugula is often used as part of a detox diet plan, and the fact that its an alkaline food is a big part of that.
ARUGULA ALSO PROVIDES HIGH LEVELS OF PROTEIN, THIAMIN, RIBOFLAVIN, VITAMIN B6, ZINC, COPPER, AND PANTOTHENIC ACID (VITAMIN B5) FOR RAISING GOOD CHOLESTEROL LEVELS AND LOWERING THE BAD. ITS FLAVONOID CONTENT HAS MULTIPLE BENEFITS: TO PREVENT CHOLESTEROL FROM STICKING TO ARTERIES,LOWER BLOOD PRESSURE, INCREASE BLOOD FLOW, LOWER INFLAMMATION, AND IMPROVE BLOOD VESSEL FUNCTION.
Dr. Mercola
Top stats (per 100g):
Calcium 16%
Vitamin A 47%
Iron 8%
Calcium 16%
Vitamin A 47%
Iron 8%
#6 ASPARAGUS

Asparagus has an alkaline effect on the body, and it just so happens that its one of the strongest foods you can eat in terms of alkalinity.
EACH FOOD IS RANKED ACCORDING TO HOW ALKALINE IT IS, AND ASPARAGUS IS ONE OF THE BIG DOGS. BUT IT BRINGS A LOT MORE THAN THAT TO THE TABLE, INCLUDING ANTIOXIDANTS, NUTRIENTS, AND PLENTY OF DETOXIFYING QUALITIES. ITS EVEN BEEN NOTED THAT ASPARAGUS HAS ANTI-AGING BENEFITS, WHICH IS ENOUGH FOR MOST PEOPLE TO START ADDING MORE OF IT TO THEIR MENU.
Bembu
Top stats (per 100g):
Vitamin A 15%
Vitamin C 9%
Iron 12%
Vitamin A 15%
Vitamin C 9%
Iron 12%
#7 AVOCADOS

Its no surprise that avocado is on our list of alkaline foods. Its managed to make it onto our list of superfoods as well, so you know its packing a nutritional punch.
AVOCADOS ARE HIGH IN POTASSIUM AS WELL AS HEALTHY FAT, SO IN ADDITION TO HELPING YOU BE MORE ALKALINE, YOURE GETTING OTHER PERKS AS WELL. YOU CAN ALSO USE AVOCADO OIL IN FAVOR OF OTHER OILS THAT DONT PROVIDE ANY ALKALINE BENEFIT, OR WORSE ARE ACID-FORMING IN THE BODY.
Top stats (per 100g):
Vitamin C 17%
Vitamin A 3%
Fiber 27%
Vitamin C 17%
Vitamin A 3%
Fiber 27%
#8 BASIL

You might not have thought that the herbs and spices you use on your food have an effect on how alkaline or acidic your pH levels are.
BUT AS IT TURNS OUT THERE ARE GOOD SPICES AND BAD SPICES. BASIL HAPPENS TO BE ONE OF THE ONES THAT HELPS KEEP YOU ALKALINE, AND IT ALSO HAS PLENTY OF OTHER THINGS GOING FOR IT, SUCH AS THE FLAVONOIDS IT CONTAINS. THESE HELP THE BODY TO HEAL AND BASIL IN GENERAL CAN HELP WITH SEVERAL DIFFERENT AREAS OF THE BODY.
Top stats (per 100g):
Vitamin A 175%
Vitamin K 345%
Calcium 18%
Vitamin A 175%
Vitamin K 345%
Calcium 18%
-
#9 BEETROOT

Beetroot gets more attention now than ever before, and its one of the foods out there that will act to help raise your pH levels.
THE REASON ITS AN IMPORTANT VEGETABLE TO INCLUDE IN YOUR ARSENAL IS BECAUSE ITS ONE OF THE ONLY SOURCES OF THE PHYTONUTRIENT BETALAIN WHICH MAY HAVE ANTI-CANCER PROPERTIES. ADD THESE AS A SIDE, OR USE THEM AS A SALAD TOPPER. BE SURE TO BUY THIS ONE FRESH AND STEAM IT, AS THE PICKLED VARIETY HAS REDUCED NUTRITIONAL VALUE.
Top stats (per 100g):
Vitamin C 8%
Vitamin K 11%
Folate 75%
Vitamin C 8%
Vitamin K 11%
Folate 75%
-
#10 BROCCOLI

This is a quintessential healthy food and its easy to understand that its an alkaline food.
BROCCOLI IS ONE OF THOSE VEGETABLES THAT HAS SO MUCH GOING ON YOU SIMPLY HAVE TO MAKE AN EXTRA EFFORT TO GET MORE OF IT INTO YOUR SYSTEM. SOME PEOPLE EAT BROCCOLI EVERY DAY AS A WAY TO MAINTAIN GOOD HEALTH AND MAKE SURE THEYRE ON THE ALKALINE SIDE. YOU AT LEAST WANT TO EAT IT MULTIPLE TIMES A WEEK, WITH 3 OR 4 TIMES BEING A GOOD RULE OF THUMB.
Top stats (per 100g):
Vitamin C 135%
Vitamin A 11%
Calcium 4%
Vitamin C 135%
Vitamin A 11%
Calcium 4%
11. Free Cookbook
Over the past year, my friend Dave over at PaleoHacks has been working on a super secret cookbook project with our good friend Peter Servold a Le Cordon Bleu trained Chef and owner of Petes Paleo... And today, this new incredible Paleo Cookbook is finally available to be shipped right to your door for FREE! Thats right -- as a special launch promotion, were offering our brand new Paleo fat loss cookbook to you for free (Chef Pete lost 60 lbs using these recipes!) -- All you have to do is just cover a small shipping cost (international shipping is a bit more).
Available link for download
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